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CAS RN: 88495-63-0 | Product Number: A2191

Artesunate


Purity: >98.0%(T)(HPLC)
Synonyms:
Documents:
5G
€33.00
7   ≥20 
25G
€93.00
5   ≥20 

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Product Number A2191
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__9H__2__8O__8 = 384.43  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 88495-63-0
Reaxys Registry Number 6003212
PubChem Substance ID 87560999
Merck Index (14) 818
MDL Number

MFCD00866204

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Melting point 132.0 to 137.0 °C
Specific rotation [a]20/D +4.5 to +6.5 deg(C=1, CH2Cl2)
Properties (reference)
Melting Point 133 °C
Specific Rotation 5.5° (C=1,CH2Cl2)
Solubility (soluble in) Methanol
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Related Laws: / Compliance with laws, Regulations
Transport Information:
HS Number 2932990090
Application
Artesunate: A Semi-Synthetic Derivative of Antimalaria Artemisinin

Artesunate is a semi-synthetic derivative of artemisinin [A2118] which is a biological active ingredient isolated from a traditional Chinese herbal medicine Artemisia annua. Artesunate is a prodrug that is rapidly converted to its active metabolite dihydroartemisinin [D3793]. Artesunate and its analogs have high efficacy against Plasmodium falciparum in the blood stages of the disease. The exact mechanism of action is still not clear, while the endoperoxide (O-O) subunit of the trioxane ring is critical for antimalarial activity. Several lines of evidence indicate that the O-O bond is easily broken by Fe2+, generating a number of reactive radicals oxidatively damage parasite. In addition, after 2000’s, the anti-tumor and antiviral activities of artesunate have been reported. (The product is for research purpose only.)

References


PubMed Literature


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