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CAS RN: 33419-42-0 | Product Number: E0675

Etoposide


Purity: >98.0%(HPLC)
Synonyms:
  • 4'-Demethylepipodophyllotoxin 9-(4,6-O-Ethylidene-β-D-glucopyranoside)
Documents:
100MG
€76.00
2   ≥20 
1G
€454.00
1   ≥20 

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*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).


Product Number E0675
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__2__9H__3__2O__1__3 = 588.56  
Physical State (20 deg.C) Solid
Condition to Avoid Light Sensitive
CAS RN 33419-42-0
Reaxys Registry Number 365969
PubChem Substance ID 87558799
Merck Index (14) 3886
Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Water max. 7.0 %
Properties (reference)
Melting Point 251 °C
Solubility in water Practically insoluble
Solubility (very soluble in) Chloroform,Methanol
Solubility (slightly sol. in) Ethanol
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H302 : Harmful if swallowed.
H360 : May damage fertility or the unborn child.
H362 : May cause harm to breast-fed children.
H371 : May cause damage to organs.
H372 : Causes damage to organs through prolonged or repeated exposure.
H340 : May cause genetic defects.
H350 : May cause cancer.
Precautionary Statements P263 : Avoid contact during pregnancy and while nursing.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor.
Related Laws:
EC Number 251-509-1
RTECS# KC0190000
Transport Information:
HS Number 2938909090
Application
Etoposide: A Topoisomerase-II Inhibitor

Etoposide (VP 16) is a semisynthetic antitumor alkaloid which is synthesized form podophyllotoxin [P1771] , a toxin found in the American Mayapple. Etoposide interferes with DNA synthesis by inhibiting the enzyme topoisomerase-II. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-II catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action leads to cell cycle arrest at G2/M, apoptosis or cell death. Bacterial type II topoisomerases (DNA gyrase and Topoisomerase-IV) are the targets of quinolone antibiotics.

References


PubMed Literature


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