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CAS RN: 78287-27-1 | Product Number: E0781

7-Ethylcamptothecin


Purity: >96.0%(HPLC)
Synonyms:
Documents:
100MG
€68.00
2   7  
1G
€406.00
2   ≥20 

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Product Number E0781
Purity / Analysis Method >96.0%(HPLC)
Molecular Formula / Molecular Weight C__2__2H__2__0N__2O__4 = 376.41  
Physical State (20 deg.C) Solid
CAS RN 78287-27-1
Reaxys Registry Number 4828556
PubChem Substance ID 87561055
MDL Number

MFCD06657922

Specifications
Appearance Light orange to Yellow to Green powder to crystal
Purity(HPLC) min. 96.0 area%
Specific rotation [a]20/D +40.0 to +46.0 deg(C=0.4, CHCl3:MeOH=8:2)
Properties (reference)
Specific Rotation 43° (C=0.4,CHCl3:MeOH=8:2)
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled.
Precautionary Statements P261 : Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell.
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.
Related Laws:
Transport Information:
UN Number UN1544
Class 6.1
Packing Group III
HS Number 2939790090
Application
7-Ethylcamptothecin: A Water Insoluble Topoisomerase-I Inhibitor

7-Ethylcamptothecin (SN-22) is a water insoluble derivative of camptothecin [C1495] with broad antitumor activity. 7-Ethylcamptothecin has been converted into water soluble derivatives such as irinotecan hydrochloride [I0714]. Camptotecin and its derivatives interfere with DNA synthesis by inhibiting the enzyme topoisomerase-I. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-I catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action induces breaks in single strand DNA. Eventually, this leads to double-strand DNA breaks and apoptosis or cell death.

References


PubMed Literature


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