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CAS RN: 19685-09-7 | Product Number: H1463


Purity: >98.0%(HPLC)
3   18  

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Product Number H1463
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__2__0H__1__6N__2O__5 = 364.36  
Physical State (20 deg.C) Solid
Storage Temperature <0°C
Condition to Avoid Heat Sensitive
CAS RN 19685-09-7
Reaxys Registry Number 3019077
PubChem Substance ID 354335739
MDL Number


Appearance White to Yellow to Orange powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 97.0 %
Properties (reference)
Melting Point 267 °C
Specific Rotation 35.3° (C=0.11,CH2Cl2:MeOH=4:1)
Maximum Absorption Wavelength 382 nm
Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled.
Precautionary Statements P261 : Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell.
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.
Related Laws:
RTECS# UQ0491700
Transport Information:
UN Number UN1544
Class 6.1
Packing Group III
HS Number 2939790090
10-Hydroxycamptothecin: An Inhibitor of Topoisomerase I with Antitumor Activity

10-hydroxycamptothecin (10-HCPT) is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. 10-HCPT, a member of the camptothecin family, interferes with DNA synthesis by inhibiting the enzyme topoisomerase-I, and has a broad spectrum of antitumor activity and less toxicity as a camptothecins.1,2) However, 10-HCPT is insoluble in both water and physiological acceptable organic solvents and tends to change into its carboxylate form, which shows minimal antitumor activity and several unpredictable side effects.3,4) Therefore, appropriate drug delivery systems (DDS) for 10-HPCT have been developed to improve the stability of its lactone form.5,6) 10-HCPT is also an important precursor for the synthesis of the clinical useful anticancer agents, such as irinotecan [I0714]. (The product is for research purpose only.)


PubMed Literature

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