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CAS RN: 1421-86-9 | Product Number: S0257

Strychnine Hydrochloride Hydrate


Purity: >98.0%(T)
Synonyms:
Documents:
25G
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Product Number S0257
Purity / Analysis Method >98.0%(T)
Molecular Formula / Molecular Weight C__2__1H__2__2N__2O__2·HCl·xH__2O = 370.88  
Physical State (20 deg.C) Solid
Condition to Avoid Light Sensitive
CAS RN 1421-86-9
Reaxys Registry Number 4927442
PubChem Substance ID 87575783
Merck Index (14) 8855
MDL Number

MFCD00058174

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 96.0 area%
Purity(Argentmetric Titration) min. 98.0 %(calcd.on anh.substance)
Specific rotation [a]20/D -27.0 to -30.0 deg(C=1, H2O)
Water max. 9.0 %
Properties (reference)
Melting Point 295 °C
Specific Rotation -29° (C=1,H2O)
Solubility in water Slightly soluble
Solubility (insoluble in) Ether
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H300 + H330 : Fatal if swallowed or if inhaled.
H410 : Very toxic to aquatic life with long lasting effects.
Precautionary Statements P273 : Avoid release to the environment.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P391 : Collect spillage.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.
Related Laws:
EC Number 215-826-9
RTECS# WL2430000
Transport Information:
UN Number UN1692
Class 6.1
Packing Group I
HS Number 2939790090
Application
Strychnine: An Indole Alkaloid with Antagonistic Activity toward Glycine and Acetylcholine Receptors

Strychnine [S0249] is an indole alkaloid obtained from the seeds and bark of Strychnos nux-vomica, has been used as a rodenticide for more than a century. Glycine is an inhibitory transmitter to motor neurons and interneurons in the spinal cord. Strychnine is a neurotoxin which acts as an antagonist of glycine and acetylcholine receptors, resulting in disinhibition of motor neurons in the spinal cord.1,2) In addition, strychnine has been a target compound for total synthesis since it was first synthesized by the group of R. B. Woodward in 1954.3,4) Strychnine is poorly soluble in water, but its sulfate [S0094], nitrate [S0093] and hydrochloride [S0257] are moderately soluble in water. (The product is for research purpose only.)

References


PubMed Literature


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