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CAS RN: 4083-64-1 | Product Number: T0998

p-Toluenesulfonyl Isocyanate


Purity: >95.0%(T)
Synonyms:
  • Tosyl Isocyanate
Documents:
25G
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100G
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500G
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Product Number T0998
Purity / Analysis Method >95.0%(T)
Molecular Formula / Molecular Weight C__8H__7NO__3S = 197.21  
Physical State (20 deg.C) Liquid
Store Under Inert Gas Store under inert gas
Condition to Avoid Moisture Sensitive
CAS RN 4083-64-1
Reaxys Registry Number 391287
PubChem Substance ID 87576806
SDBS (AIST Spectral DB) 13756
MDL Number

MFCD00002030

Specifications
Appearance Colorless to Almost colorless clear liquid
Purity(Neutralization titration) min. 95.0 %
Specific gravity (20/20) 1.2970 to 1.2990
Refractive index n20/D 1.5340 to 1.5360
Properties (reference)
Melting Point -2 °C
Boiling Point 130 °C/6 mmHg
Flash point 145 °C
Specific Gravity (20/20) 1.30
Refractive Index 1.53
Solubility (soluble in) Toluene,Acetone
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H332 : Harmful if inhaled.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H335 : May cause respiratory irritation.
Precautionary Statements P261 : Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P284 : Wear respiratory protection.
P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor.
P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell.
Related Laws:
EC Number 223-810-8
RTECS# DB9032000
Transport Information:
HS Number 2935909099
Application
Derivatization Reagent of Hydroxyl Group for LC-MS

References


Application
A Novel Hydroxy Protecting Group: Sulfonylcarbamate Group

T0998

Typical Procedure:
[Protection of Hydroxy Groups]
To a solution of alcohol (1.0 mmol) in THF (5 mL), p-toluenesulfonyl isocyanate (1.1 mmol) is added at room temperature. The mixture is stirred under N2 atmosphere. After the starting material has disappeared by TLC analysis, (the mixture is extracted with EtOAc, and) the solvent is evaporated. The residue is purified by silica gel column chromatography to afford the product.
[Removal of the Protecting Group by Pyridine―MeOH]
A solution of sulfonylcarbamate (100 mg) in pyridine―MeOH (7 : 3, 5 mL) is stirred at 50 °C until the starting material is consumed. After evaporation, the residue is purified by silica gel column chromatography.

References


Application
Synthesis of N-Acylsulfonamides

References


PubMed Literature


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