CAS RN: 4083-64-1 | Product Number: T0998
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|Purity / Analysis Method||>95.0%(T)|
|Molecular Formula / Molecular Weight||C__8H__7NO__3S = 197.21|
|Physical State (20 deg.C)||Liquid|
|Store Under Inert Gas||Store under inert gas|
|Condition to Avoid||Moisture Sensitive|
|Reaxys Registry Number||391287|
|PubChem Substance ID||87576806|
|SDBS (AIST Spectral DB)||13756|
|Appearance||Colorless to Almost colorless clear liquid|
|Purity(Neutralization titration)||min. 95.0 %|
|Specific gravity (20/20)||1.2970 to 1.2990|
|Refractive index n20/D||1.5340 to 1.5360|
|Melting Point||-2 °C|
|Boiling Point||130 °C/6 mmHg|
|Flash point||145 °C|
|Specific Gravity (20/20)||1.30|
|Solubility (soluble in)||Toluene,Acetone|
|Hazard Statements||H332 : Harmful if inhaled.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H335 : May cause respiratory irritation.
|Precautionary Statements||P261 : Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P284 : Wear respiratory protection.
P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor.
P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell.
- p-Toluenesulfonyl isocyanate as a novel derivatization reagent to enhance the electrospray ionization and its application in the determination of two stereo isomers of 3-hydroxyl-7-methyl-norethynodrel in plasma
- Development and validation of an LC–ESI/MS/MS method with precolumn derivatization for the determination of betulin in rat plasma
[Protection of Hydroxy Groups]
To a solution of alcohol (1.0 mmol) in THF (5 mL), p-toluenesulfonyl isocyanate (1.1 mmol) is added at room temperature. The mixture is stirred under N2 atmosphere. After the starting material has disappeared by TLC analysis, (the mixture is extracted with EtOAc, and) the solvent is evaporated. The residue is purified by silica gel column chromatography to afford the product.
[Removal of the Protecting Group by Pyridine―MeOH]
A solution of sulfonylcarbamate (100 mg) in pyridine―MeOH (7 : 3, 5 mL) is stirred at 50 °C until the starting material is consumed. After evaporation, the residue is purified by silica gel column chromatography.
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