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CAS RN: 162635-04-3 | Product Number: T3574


Purity: >95.0%(HPLC)
  • CCI-779
  • Rapamycin 42-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate]
1   5  
1   15  

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Product Number T3574
Purity / Analysis Method >95.0%(HPLC)
Molecular Formula / Molecular Weight C__5__6H__8__7NO__1__6 = 1030.3  
Physical State (20 deg.C) Solid
CAS RN 162635-04-3
Reaxys Registry Number 9985459
PubChem Substance ID 354335686
Merck Index (14) 9142
MDL Number


Appearance White to Almost white powder to crystal
Purity(HPLC)(CAD) min. 95.0 area%
Properties (reference)
Solubility in water Insoluble
Degree of solubility in water 0.00005 mg/l   25 °C
Solubility (soluble in) Alcohol,Ethanol
Pictogram Pictogram
Signal Word Danger
Hazard Statements H360 : May damage fertility or the unborn child.
H413 : May cause long lasting harmful effects to aquatic life.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P273 : Avoid release to the environment.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
Related Laws:
RTECS# VE6257000
Transport Information:
HS Number 2934999090
Temsirolimus: An Inhibitor of Mammalian Target of Rapamycin (mTOR)

Temsirolimus (also called CCI-779) is an inhibitor of mammalian target of rapamycin (mTOR), a serine/threonine protein kinase. Temsirolimus, the C-42 hydroxyl group ester analog of rapamycin [R0097], possesses better water solubility. Similarly to rapamycin, temsirolimus forms a complex with FK506-binding protein-12 (FKBP-12), and this complex binds and specifically acts as an allosteric inhibitor of mTOR. Inhibition of mTOR activity interferes with tumor angiogenesis,and resulted in a G1 growth arrest in treated tumor cells. (The product is for research purpose only.)


PubMed Literature

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