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CAS RN: 68302-57-8 | Product Number: A2401
Amlexanox
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-Amino-7-isopropyl-5-oxochromeno[2,3-b]pyridine-3-carboxylic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€50.00
|
1 | 1 |
|
| 5G |
€159.00
|
1 | 30 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A2401 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__4N__2O__4 = 298.30 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 68302-57-8 |
| Reaxys Registry Number | 556384 |
| PubChem Substance ID | 160871486 |
| Merck Index (14) | 490 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 300 °C |
GHS
Related Laws:
| RTECS# | DJ3102000 |
Transport Information:
| HS Number | 2934999090 |
Application
Amlexanox: A Specific Inhibitor of IKKε and TBK1 with Anti-Allergic Activity
Amlexanox (AA-673) is an anti-inflammatory and anti-allergic agent. The precise mechanism of action is known, but recently in vitro studies have demonstrate that amlexanox is a specific inhibitor of the protein kinases IκB kinase-ε (IKKε) and TANK-binding kinase 1 (TBK1) resulting in the inhibition of the formation and/or release of inflammatory mediators (histamine and leukotrienes) from mast cells, neutrophils and mononuclear cells. For your reference, [C2661] is a synthetic intermediate of amoxanox. (The product is for research purpose only.)
References
- Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase
- Three distinct anti-allergic drugs, amlexanox, cromolyn and tranilast, bind to S100A12 and S100A13 of the S100 protein family
- Two distinct anti-allergic drugs, amlexanox and cromolyn, bind to the same kinds of calcium binding proteins, except calmodulin, in bovine lung extract
- Amlexanox reversibly inhibits cell migration and proliferation and induces the Src-dependent disassembly of actin stress fibers in Vitro
- An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice
- A validated stability indicating LC method for amlexanox in bulk drugs
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