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Published TCIMAIL newest issue No.199
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CAS RN: 23007-85-4 | Product Number: M2690
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride
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Purity: >98.0%(HPLC)
Synonyms:
- MPTP Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
€84.00
|
1 | ≥80 |
|
| 100MG |
€218.00
|
3 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | M2690 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__2H__1__5N·HCl = 209.72 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image), 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 23007-85-4 |
| Related CAS RN
|
28289-54-5 |
| Reaxys Registry Number | 3707312 |
| PubChem Substance ID | 253660522 |
| MDL Number | MFCD00012790 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 249.0 to 254.0 °C |
Properties (reference)
| Melting Point | 250 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | UT8358950 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2933399999 |
Application
パーキンソン病 (PD) モデル動物作成用の神経毒，MPTP塩酸塩
MPTP hydrochloride can lead to severe damage to the nigrostriatal dopaminergic system similar to that observed in Parkinson’s disease (PD). Therefore, it has been used to PD animal models. (The product is for research purpose only.)
References
- 1)Mitochondrial complex I deficiency in Parkinson's disease
- 2)Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease
- 3)Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease
- 4)Experimental models of Parkinson's disease (a review)
- 5)Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease (a review)
PubMed Literature
Product Articles
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