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CAS RN: 6600-40-4 | Product Number: N0686
L-Norvaline
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Purity: >99.0%(T)
Synonyms:
- (S)-2-Aminopentanoic Acid
- (S)-2-Aminovaleric Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
18,00 €
|
1 | 7 |
|
|
| 5G |
58,00 €
|
2 | 7 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | N0686 |
Purity / Analysis Method 
|
>99.0%(T) |
| Molecular Formula / Molecular Weight | C__5H__1__1NO__2 = 117.15 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 6600-40-4 |
| Reaxys Registry Number | 1721162 |
| PubChem Substance ID | 87573997 |
| Merck Index (14) | 6716 |
| MDL Number | MFCD00064421 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(Nonaqueous Titration) | min. 99.0 % |
| Optical purity(HPLC) | min. 98.0 ee% |
| Solubility in Water | almost transparency |
| NMR | confirm to structure |
Properties (reference)
| Specific Rotation | 25° (C=10,6mol/L HCl) |
GHS
Related Laws:
| EC Number | 229-543-3 |
Transport Information:
| HS Number | 2922498540 |
Application
Bacterial spore germinant research
Bacterial spores are more resistant to antibiotics and nutritional deficiencies than their vegetative cells and sometimes cause serious problems from the viewpoint of hygiene in clinical treatment and food processing.1) Spore persistence also plays a major role in the recurrence of infections after antibiotic treatment. Molecules that stimulate germination are termed “germinants”1) and the efficacy of germinant administration combined with antibiotics have been evaluated (for example, reports by N. Budi et al.2,3)). Cogerminants are compounds that do not have germination-stimulating activity in themselves but stimulate germination when combined with other compounds. L-Norvaline has been reported to act as a cogerminant in combination with taurocholate (T0808) for Clostridium difficile spore.4) For Clostridium frigidicarnis spores, the amino acid was demonstrated to act as a cogerminant when used with L-lactate (L0165) and cogerminants, NaHCO3 (S0561) and L-cysteine (C0515).5)
(The product is for research purpose only.)
(The product is for research purpose only.)
References
- 1) Germinants and Their Receptors in Clostridia
- 2) Omadacycline compared to vancomycin when combined with germinants to disrupt the life cycle of Clostridioides difficile.
- 3) Efficacy of Omadacycline or Vancomycin Combined With Germinants for Preventing Clostridioides difficile Relapse in a Murine Model
- 4) Mapping Interactions between Germinants and Clostridium difficile Spores
- 5) Spore germination of the psychrotolerant, red meat spoiler, Clostridium frigidicarnis
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