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CAS RN: 95975-55-6 | Product Number: G0629

Guggulsterone [mixture of (E)- and (Z)- isomers]

Chemical Structure of Guggulsterone [mixture of (E)- and (Z)- isomers]
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× Guggulsterone [mixture of (E)- and (Z)- isomers]

Purity: >98.0%(HPLC)
Synonyms:
  • Pregna-4,17(20)-diene-3,16-dione [mixture of (E)- and (Z)- isomers]
  • Pregna-4,17-diene-3,16-dione [mixture of (E)- and (Z)- isomers]
Product Documents:
SDS | Specifications | C of A & Other Certificates | Analytical Charts

General Information | Specifications & Properties | Safety & Regulations | Applications & Literature

Explanatory notes for this page

250MG
S$471.00
 10   18   Contact Us
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Product Number G0629
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__2__1H__2__8O__2 = 312.45 
Physical State (20 deg.C) Solid
Storage Temperature Room Temperature (Recommended in a cool and dark place, <15°C)
CAS RN 95975-55-6
Reaxys Registry Number 5294518
MDL Number

MFCD01310757
Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 %(total of isomers)
NMR confirm to structure
Properties (reference)
GHS
Related Laws:
RTECS# TU3670500
Transport Information:
H.S.code* 2914.29-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Guggulsterone: A Bioactive Plant Sterol

Guggulsterone is a plant sterol and bioactive compound found in the gum guggul of Commiphora wightii, which has been used as a traditional herbal medicine. Guggulsterone has been reported to bind to the farnesoid X receptor (FXR), a member of the nuclear hormone receptor superfamily, and decrease the expression of bile acid-activated genes.1) Guggulsterone has been found to potently inhibit the activation of nuclear factor-κB (NF-κB), a critical regulator of inflammatory responses.1) Furthermore, guggulsterone modulates the expression of proteins with anti-apoptotic (IAP1, XIA, P, Bfl-1/A1, Bcl-2, cFLIP, survivin), cell survival, cell proliferation (cyclin D1, c-Myc), angiogenic, and metastatic (MMP-9, COX-2, VEGF) activities in tumor cells.1-5) (The product is for research purpose only.)

References


Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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Analytical Charts
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Other Documents

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