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CAS RN: 338967-87-6 | Product Number: M3108
Mdivi-1
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Purity: >95.0%(HPLC)
Synonyms:
- 3-(2,4-Dichloro-5-methoxyphenyl)-2-thioxo-2,3-dihydro-4(1H)-quinazolinone
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time | Quantity |
Shipping Information
|
|---|---|---|---|---|---|---|
| 10MG |
S$190.50
|
1 | 0 | It can be shipped in about 2 weeks after ordering |
|
|
| 50MG |
S$663.00
|
9 | 5 | It can be shipped in about 2 weeks after ordering |
|
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to order TCI products.
* The storage conditions are subject to change without notice.
| Product Number | M3108 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__0Cl__2N__2O__2S = 353.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
10MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 338967-87-6 |
| Reaxys Registry Number | 23802926 |
| PubChem Substance ID | 354335750 |
| MDL Number | MFCD00974506 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
Properties (reference)
| Melting Point | 289 °C |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2933.79-000 |
Application
Mdivi-1: A Selective Cell-Permeable Inhibitor of Mitochondrial Fission
Mitochondria play a key role in maintaining cellular metabolic homeostasis, and its fission and fusion play important roles in in several pathological conditions. Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp-1) is an attractive drug target in numerous maladies that range from heart disease to neurodegenerative disorders.
Mdivi-1 (mitochondrial division inhibitor 1) has been reported to inhibit selectively Drp-1 dependent fission with cell permeability. Inhibiting mitochondrial fission with Mdivi-1 has proven cytoprotective benefits in several cell types involved in a wide array of cardiovascular injury models. (The product is for research purpose only.)
Mdivi-1 (mitochondrial division inhibitor 1) has been reported to inhibit selectively Drp-1 dependent fission with cell permeability. Inhibiting mitochondrial fission with Mdivi-1 has proven cytoprotective benefits in several cell types involved in a wide array of cardiovascular injury models. (The product is for research purpose only.)
References
- Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization
- Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models
- Small Molecule Inhibitors of Mitochondrial Division: Tools that Translate Basic Biological Research into Medicine (a review)
- Mitochondrial fusion by pharmacological manipulation impedes somatic cell reprogramming to pluripotency: new insight into the role of mitophagy in cell stemness (a review)
- Mitochondrial fission - a drug target for cytoprotection or cytodestruction? (a review)
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