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CAS RN: 123447-62-1 | Product Number: P2058
Prulifloxacin
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
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| Product Number | P2058 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__0FN__3O__6S = 461.46 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 123447-62-1 |
| Reaxys Registry Number | 5894071 |
| PubChem Substance ID | 253660145 |
| Merck Index (14) | 7908 |
| MDL Number | MFCD00864847 |
Specifications
| Appearance | Light orange to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 220 °C(dec.) |
| Maximum Absorption Wavelength | 276 nm (H__2O) |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Dimethylformamide |
| Solubility (insoluble in) | Ether |
GHS
Related Laws:
| RTECS# | XJ0600000 |
Transport Information:
| H.S.code* | 2941.90-000 |
Application
A Broad-Spectrum Fluoroquinolone Antibacterial Agent, Prulifloxacin
Prulifloxacin (PUFX), the prodrug of ulifloxacin (NM394), is a broad-spectrum fluoroquinolone antibacterial agent. After absorption, prulifloxacin is metabolized by esterases to ulifloxacin. Ulifloxacin, the active form of prulifloxacin, is generally more active than other fluoroquinolones against a variety of Gram-positive and Gram-negative bacteria including Pseudomonas aeruginosa.
References
- Prulifloxacin
- Pharmacologic characteristics of prulifloxacin
- Polyamidoamine (PAMAM) dendrimers as biocompatible carriers of quinolone antimicrobials: An in vitro study
- Paraoxonase has a major role in the hydrolysis of prulifloxacin (NM441), a prodrug of a new antibacterial agent
- K. Tougou, A. Nakamura, S. Watanabe, Y. Okuyama, A. Morino, Drug Metab. Dispos. 1998, 26, 355.
- Comparative assessment of prulifloxacin, sparfloxacin, gatifloxacin and levofloxacin in the rabbit model of proarrhythmia
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