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CAS RN: 139264-17-8 | Product Number: Z0024
Zolmitriptan
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (S)-4-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time | Quantity |
Shipping Information
|
|---|---|---|---|---|---|---|
| 200MG |
S$97.50
|
0 | 5 | Contact Us |
|
|
| 1G |
S$340.50
|
28 | 13 | Contact Us |
|
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| Product Number | Z0024 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__2__1N__3O__2 = 287.36 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 139264-17-8 |
| Reaxys Registry Number | 7415010 |
| PubChem Substance ID | 253659590 |
| Merck Index (14) | 10189 |
| MDL Number | MFCD00871503 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 136.0 to 140.0 °C |
| Specific rotation [a]20/D | -3.0 to -5.0 deg(C=1、MeOH) |
Properties (reference)
| Melting Point | 138 °C |
| Specific Rotation | -4° (C=1,MeOH) |
| Maximum Absorption Wavelength | 225 nm |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | RQ2707000 |
Transport Information:
| H.S.code* | 2934.99-000 |
Application
Zolmitriptan: A Selective 5-HT1B/1D Receptor Agonist
Zolmitriptan is a selective 5-HT1B/1D receptor agonist, belongs to triptans. Zolmitriptan binds with high affinity to 5-HT1 receptor subtypes (5-HT1B, 5-HT1D), and moderate affinity for a serotonergic receptor subtype (5-HT1A). Zolmitriptan is mainly metabolized by CYP1A2 to an initial metabolite N-desmethylzolmitriptan which also has high affinity for 5-HT1B/1D and moderate affinity for 5-HT1A receptors. Animal studies shows that zolmitriptan presumably exerts its therapeutic effects in the treatment of migraine headache through agonist effects at the 5-HT1B/1D receptors on intracranial blood vessels and sensory nerves of the trigeminal system. (The product is for research purpose only.)
References
- Inhibition of trigeminal neurons by intravenous administration of the serotonin (5HT)1B/D receptor agonist zolmitriptan (311C90): are brain stem sites therapeutic target in migraine?
- Receptor specificity and trigemino-vascular inhibitory actions of a novel 5-HT1B/1D receptor partial agonist, 311C90 (zolmitriptan)
- Zolmitriptan - a 5-HT1B/D agonist, alcohol, and aggression in mice
- Characterization of 5-HT receptors in human coronary arteries by molecular and pharmacological techniques
- Determination of the human cytochrome P450 isoforms involved in the metabolism of zolmitriptan
- Simultaneous measurement of zolmitriptan and its major metabolites N-desmethylzolmitriptan and zolmitriptan N-oxide in human plasma by high-performance liquid chromatography with coulometric detection
- High-performance liquid chromatographic analysis of zolmitriptan in human plasma using fluorescence detection
- A validated chiral LC method for the determination of Zolmitriptan and its potential impurities
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