Combretastatin A4 (CA4) is an antitumor compound isolated from the African bush willow tree (Combretum caffrum).1) CA4 binds to tubulin dimers and inhibits microtubule polymerization, thereby inducing mitotic arrest and apoptosis in endothelial cells.1,2) Combretastatin A4 phosphate disodium salt (CA4P), a water-soluble prodrug of CA4, is converted to CA4 by metabolism.3) It has been reported that CA4P has significant effects on tumor vascularization by disrupting vascular endothelial cadherin.4,5) Recently CA4 was also extracted from Brazilian Combretaceae family plant (Combretum leprosum).6) And various CA4 analogs have been synthesized and evaluated for antitumor activity.7,8)
(The products are for research purpose only.)
Maintenance Notice (11:00 PM August 15 - 1:30 AM August 16, 2026 UTC): The website is scheduled for maintenance. The website will be available, but some functions may experience errors. We appreciate your patience and understanding.
Product Document Searching Made Easy by 2D Code! | TCI Chemistry News August 2026 | [Product Highlights] Chain Transfer Agents for Cationic RAFT... | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
