Dorsomorphin (1) is a potent inhibitor of AMP-activated protein kinase (AMPK).1) AMPK is inhibited by 1 with
Ki = 109 nM. However, 1 does not significantly inhibit structurally related kinases, including spleen tyrosine kinase (SYK), zeta-chain-associated protein kinase (ZAPK), protein kinase A (PKA), protein kinase Cθ (PKCθ), and Janus kinase (JAK).
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