TCI使用Cookie来个性化和改善您的用户体验,您可以访问我们的隐私权政策 了解更多信息。
Product Document Searching Made Easy by 2D Code! | TCI Chemistry News June 2025 | [Product Highlights] Benzoquinone Derivative Useful for... | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
Maximum quantity allowed is 999
酪氨酸激酶抑制剂 [抗肿瘤药]
Tyrosine kinase is an enzyme that phosphorylates the hydroxyl group of the side chain of tyrosine residues in proteins. When a protein kinase phosphorylates substrate proteins by transferring phosphate from ATP to a substrate protein, the three-dimensional structure of the substrate protein changes and its activity is altered. This change also modulates the cell function.
Serine/threonine kinases have been known as typical intracellular protein kinases. However, since the oncogene product of retrovirus was found to work as a tyrosine kinase, various new tyrosine kinases have been reported. The tyrosine kinases are cell growth factor receptors and oncogene products, so they are the research targets for cell signaling, cell proliferation and carcinogenesis.
TCI offers small molecule inhibitors for tyrosine kinases involved in cancer research.
Topics
- Tyrosine Kinase Iinhibitor: Biochanin A
- FGFR/VEGFR Tyrosine Kinase Inhibitor: PD173074
- JAK Inhibitor: Tyrphostin AG490
- RET Kinase Inhibitor: RPI 1
- Tyrosine Kinase Inhibitor: Methyl 2,5-Dihydroxycinnamate
- Tyrosine Kinase Inhibitor: Tyrphostin AG1478
- Tyrosine Kinase Inhibitor: Tyrphostin AG 494
Related Category Pages
- Cancer Research
- Antitumor Ingredients (for Research and Experimental Use)
- Kinase/Phosphatase Biology
References
- 1) From oncogene to drug: development of small molecule tyrosine kinase inhibitors as anti-tumor and anti-angiogenic agents
- 2) Transforming gene product of Rous sarcoma virus phosphorylates tyrosine
- 3) Signal transduction by receptors with tyrosine kinase activity