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CAS RN: 1937-19-5 | 产品编码: A1129
Aminoguanidine Hydrochloride
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity( Potassium iodate Method) | min. 98.0 % |
| Melting point | 161.0 to 167.0 °C |
物性（参考值）
| 熔点 | 165 °C |
| 溶解性（可溶于） | 醇 |
| 溶解性（不溶于） | 乙醚 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
| RTECS# | ME8430000 |
运输信息
| HS编码* | 2925.29-000 |
应用
Two Biological Effects of Aminoguanidine Hydrochloride
It is reported that aminoguanidine hydrochloride has two important biological effects. Firstly, it is effective for the prevention of formation of advanced glycation endproducts (AGEs) associated with pathogenesis of secondary complications to diabetes and with cardiovascular changes in aging.1-3) Aminoguanidine hydrochloride reacts rapidly with in vivo glycation α,β-dicarbonyl products such as methylglyoxal, glyoxal [G0152], and 3-deoxyglucosone to prevent the formation of AGEs.
Secondly, it inhibits of the individual isoforms of nitric oxide synthase (iNOS) which is one of three key enzymes generating nitric oxide (NO) from L-arginine [ A0526]. iNOS-derived nitric oxide plays an important role in numerous physiological (e.g. blood pressure regulation) and pathophysiological (e.g. inflammation) conditions. 3-6) (The product is for research purpose only.)
Secondly, it inhibits of the individual isoforms of nitric oxide synthase (iNOS) which is one of three key enzymes generating nitric oxide (NO) from L-arginine [ A0526]. iNOS-derived nitric oxide plays an important role in numerous physiological (e.g. blood pressure regulation) and pathophysiological (e.g. inflammation) conditions. 3-6) (The product is for research purpose only.)
References
- 1)Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking
- 2)Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts (a review)
- 3)Biological effects of aminoguanidine: An update (a review)
- 4)Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction
- 5)Selective inhibition of the inducible nitric oxide synthase by aminoguanidine
- 6)Selective inhibition of inducible nitric oxide synthase by aminoguanidine (a review)
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