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CAS RN: 957-68-6 | 产品编码: A1266
7-Aminocephalosporanic Acid
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| 产品编码 | A1266 |
| 纯度/分析方法 | >97.0%(T)(HPLC) |
| 分子式/分子量 | C__1__0H__1__2N__2O__5S = 272.28 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| CAS RN | 957-68-6 |
| PubChem物质ID | 87562732 |
| Merck Index (14) | 434 |
| MDL编号 | MFCD00005177 |
技术规格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
| Specific rotation [a]20/D | +88.0 to +94.0 deg(C=0.5, buffer sol.pH7.0 KH2PO4) |
| NMR | confirm to structure |
物性（参考值）
| 比旋光度 [α]D | 90° (C=0.5,buffer sol. pH7.0 KH2PO4) |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P272 : Contaminated work clothing should not be allowed out of the workplace. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P284 : Wear respiratory protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. |
相关法规
运输信息
| HS编码* | 2934.99-000 |
应用
7-Aminocephalosporanic Acid (7-ACA): a Starting Compound for Semisynthetic Cephalosporin Antibiotics.
The enzymatic conversion of cephalosporin C gives 7-aminocephalosporanic acid (7-ACA) [A1266], which is used as a starting compound for semisynthetic cephalosporin antibiotics. Modification of 7-ACA at the 3- and 7-positions gives rise to a number of third and fourth semisynthetic cephalosporin antibiotics that are significantly generally more active against Gram-negative bacteria than first and second generation ones. Differences in side chain structure at the 7-position directly affect their antibiotic activity, whereas modifications made at the 3-position influence their metabolism and pharmacokinetic properties of the drugs.
References
- Development of the semi-synthetic penicillins and cephalosporins
- Enzymatic Deprotection of the Cephalosporin 3’-Acetoxy Group Using Candida antarctica Lipase B
- Synthesis and antibacterial properties of 7-[2-(3-substituted-5-isoxazolyl)-2-methoxyiminoacetamidojcephalosporanic acid derivatives
- Synthesis and biological activity of novel 3-(2-propenyl)-cephalosporins. I.
- Studies on orally active cephalosporinsi. Synthesis and structure-activity relationships of new 3-substituted carbamoyloxymethyl cephalosporins
- Antimicrobial Agents: Antibacterials and Antifungals (a book review)
参考文献
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