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CAS RN: 63968-64-9 | 产品编码: A2118
Artemisinin
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| 产品编码 | A2118 |
纯度/分析方法 
|
>97.0%(HPLC) |
| 分子式/分子量 | C__1__5H__2__2O__5 = 282.34 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 63968-64-9 |
| Reaxys-RN | 4194670 |
| PubChem物质ID | 87560451 |
| Merck Index (14) | 817 |
| MDL编号 | MFCD00081057 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Melting point | 151.0 to 155.0 °C |
| Specific rotation [a]20/D | +70.0 to +80.0 deg(C=0.5, MeOH) |
物性（参考值）
| 熔点 | 153 °C |
| 比旋光度 [α]D | 75° (C=0.5,MeOH) |
| 溶解性（可溶于） | 甲醇 |
GHS
相关法规
| RTECS# | KD4170000 |
运输信息
| HS编码* | 2932.99-000 |
应用
Artemisinin: An Antimalarial Sesquiterpene Lactone
Artemisinin is a fast-acting and widely used antimalarial agent. Artemisinin was first isolated in 1971 from Chinese medicinal herb Artemisia annua by Tu, a Chinese scientist, who was awarded the Nobel Prize in Physiology or Medicine with Omura and Campbell in 2015. After the activity of artemisinin had been established, several analogs such as such as artemether [A2190], artesunate [A2191] and dihydroartemisinin [D3793] were developed to improve bioavailability and efficacy. Artemisinin and its analogs have high efficacy against Plasmodium falciparum in the blood stages of the disease. The exact mechanism of action is still not clear, while the endoperoxide (O-O) subunit of the trioxane ring is critical for antimalarial activity. Several lines of evidence indicate that the O-O bond is easily broken by Fe2+, generating a number of reactive radicals oxidatively damage parasite. (The product is for research purpose only.)
References
- Qinghaosu (artemisinin): an antimalarial drug from China (a review)
- Artemisinin: mechanisms of action, resistance and toxicity (a review)
- Antimalarial activity of mefloquine and qinghaosu
- Total synthesis of qinghaosu
- The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine
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