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CAS RN: 39831-55-5 | 产品编码: A2281
Amikacin Sulfate
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纯度/分析方法: >98.0%(HPLC)
别名：
- 硫酸阿米卡星
- 阿米卡星二硫酸盐
- O-3-氨基-3-脱氧-α-D-吡喃葡萄糖基-(1→6)O-[6-氨基-6-脱氧-α-D-吡喃葡萄糖基-(1→4)]-N1-[(2S)-4-氨基-2-羟基-1-氧代丁基]-2-脱氧-D-链霉胺硫酸盐
- Amikacin Disulfate
- O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptamine Sulfate
产品文档：
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC)(CAD) | min. 98.0 area% |
| Specific rotation | +76.0 to +84.0 deg(C=1, water)(calcd.on anh.substance) |
| Water | max. 13.0 % |
物性（参考值）
| 熔点 | 230 °C(dec.) |
GHS
相关法规
| RTECS# | WK1961200 |
运输信息
| HS编码* | 2941.90-000 |
应用
Amikacin sulfate: A Polycationic Bactericidal Aminoglycoside
Amikacin sulfate is a polycationic, semisynthetic, bactericidal aminoglycoside. Amikacin was synthesized by acylation with the L-(-)-γ-amino-α-hydroxybutyryl side chain at the C-1 amino group of the deoxystreptamine moiety of kanamycin [K0047]. Amikacin is very active against most Gram-negative bacteria including gentamicin- [G0383] and tobramycin- [T2503] resistant strains. Amikacin enters the bacterial cell by binding to negatively charged components of the bacterial cell wall disrupting the overall architecture of the cell wall. The mechanism of action is disruption and inhibition of protein synthesis in the target bacteria by binding to the 30S ribosomal subunit.1,2) In addition, amikacin is devoid of any chromophore and/or conjugated system prerequisite for UV and florescent light detection (FLD). Hence, simple and sensitive liquid chromatography methods have been developed for the determination of amikacin.3-5) (The product is for research purpose only.)
References
- (1) The aminoglycosides (a review)
- (2) Amikacin: uses, resistance, and prospects for inhibition (a review)
- (3) Determination of amikacin in body fluid by high-performance liquid-chromatography with chemiluminescence detection
- (4) Development and validation of a novel LC non-derivatization method for the determination of amikacin in pharmaceuticals based on evaporative light scattering detection
- (5) Amikacin sulfate (a review of the profile, physical properties, synthesis, metabolism and pharmacokinetics, stability and methods for determination of amikacin)
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