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CAS RN: 77337-73-6 | 产品编码: A2359
Acamprosate Calcium
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| 产品编码 | A2359 |
纯度/分析方法 
|
>98.0%(HPLC) |
| 分子式/分子量 | C__1__0H__2__0CaN__2O__8S__2 = 400.47 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 77337-73-6 |
| 相关CAS RN
|
77337-76-9 |
| Reaxys-RN | 8945911 |
| PubChem物质ID | 125307900 |
| SDBS (AIST Spectral DB) | 52940 |
| Merck Index (14) | 17 |
| MDL编号 | MFCD00886588 |
技术规格
| Appearance | White to Almost white powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Chelometric Titration) | min. 97.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 270 °C |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
| RTECS# | TZ6357000 |
运输信息
| HS编码* | 2924.19-000 |
应用
Neuroprotective Effects of Acamprosate Calcium
Acamprosate calcium is a synthetic compound with a chemical structural similar of the endogenous amino acid homotaurine [A2602], and a structural analogue of the amino acid neurotransmitter γ-aminobutyric acid (GABA) [A0282] and the amino acid neuromodulator taurine [A0295]. The precise mechanism is not fully understood, but there is evidence to suggest that acamprosate may interact with glutamate and GABA, excitatory and inhibitory neurotransmitter systems centrally, and has led to the hypothesis that acamprosate restores this balance. Acamprosate calcium is widely used in the treatment of alcohol dependence in clinical. (The product is for research purpose only.)
References
- Mechanism of action of acamprosate. Part I. Characterization of spermidine-sensitive acamprosate binding site in rat brain
- The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801
- Ethanol and amino acids in the central nervous system: assessment of the pharmacological actions of acamprosate(a review)
- Neuroprotective and abstinence-promoting effects of acamprosate: elucidating the mechanism of action (a review)
- Validation of a capillary electrophoresis procedure for the determination of calcium in calcium acamprosate
- Analysis of acamprosate in beagle dog plasma by LC-MS-MS
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