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CAS RN: 120511-73-1 | 产品编码: A2370
Anastrozole
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| 产品编码 | A2370 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__7H__1__9N__5 = 293.37 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
100MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 120511-73-1 |
| Reaxys-RN | 8005958 |
| PubChem物质ID | 135727309 |
| MDL编号 | MFCD00866298 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 82.0 to 86.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 84 °C |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | CZ1465000 |
运输信息
| UN编号 | UN3439 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2933.99-000 |
应用
Anastrozole: A Potent and Selective Aromatase Inhibitor
Anastrozole is a third generation, and a potent and selective aromatase inhibitor. Aromatase is responsible enzyme for the aromatization of androgens into estrogens in the periphery. Anastrozole inhibits aromatase and estrogen synthesis, resulting in suppressing tumor growth. Anastrozole alone or a combination agent with tamoxifen citrate [T2510] is used for the treatment for postmenopausal women with breast cancer. (The product is for research purpose only.)
References
- Influence of anastrozole (Arimidex), a selective, non-steroidal aromatase inhibitor, on in vivo aromatization and plasma estrogen levels in postmenopausal women with breast cancer
- The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033) - a potent, selective aromatase inhibitor
- Inhibition of human drug metabolizing cytochromes P450 by anastrozole, a potent and selective inhibitor of aromatase
- Aromatase inhibitors in the treatment of breast cancer (a review)
- Development and validation of a simple and sensitive high performance liquid chromatographic method for the simultaneous determination of anastrozole, bicalutamide, tamoxifen, and their synthetic impurities
参考文献
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