Maximum quantity allowed is 999
请选择数量
CAS RN: 154229-19-3 | 产品编码: A2868
Abiraterone
×
![]()
×
| 产品编码 | A2868 |
纯度/分析方法 
|
>98.0%(HPLC) |
| 分子式/分子量 | C__2__4H__3__1NO = 349.52 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器
|
200MG-Glass Bottle with Plastic Insert （查看图片）, 20MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 154229-19-3 |
| Reaxys-RN | 7309269 |
| PubChem物质ID | 253661112 |
| MDL编号 | MFCD00924100 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Melting point | 226.0 to 230.0 °C |
| Specific rotation [a]20/D | -57.0 to -65.0 deg (C=0.5,CHCl3) |
物性（参考值）
| 熔点 | 228 °C |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. H373 : May cause damage to organs through prolonged or repeated exposure. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
运输信息
| HS编码* | 2933.39-000 |
应用
Abiraterone: A Selective Inhibitor of the Steroidogenic Enzyme Cytochrome P450 17A1 (CYP17A1)
Abiraterone is a selective inhibitor of the steroidogenic enzyme cytochrome P450 17A1 (CYP17A1) which catalyzes two key serial reactions (17α-hydroxylase hydroxylase and 17,20-lyase) in androgen and estrogen biosynthesis. Abiraterone acetate [A2891] (of which the active metabolite is abiraterone) is an agent used in combination with prednisone [P1276] in metastatic castration-resistant prostate cancer (mCRPC). (The product is for research purpose only.)
References
- The 16,17-Double Bond Is Needed for Irreversible Inhibition of Human Cytochrome P45017α by Abiraterone (17-(3-Pyridyl)androsta-5,16-dien-3β-ol) and Related Steroidal Inhibitors
- Significant and sustained antitumor activity in post-docetaxel, castration-resistant prostate cancer with the CYP17 inhibitor abiraterone acetate
- Resistance to CYP17A1 Inhibition with Abiraterone in Castration-Resistant Prostate Cancer: Induction of Steroidogenesis and Androgen Receptor Splice Variants
- Antitumor activity with CYP17 blockade indicates that castration-resistant prostate cancer frequently remains hormone driven (a review)
- CYP17 inhibitors-abiraterone, C17,20-lyase inhibitors and multi-targeting agents (a review)
参考文献
技术文章
产品文档 (部分产品的分析图谱无法提供，敬请谅解。)
化学品安全说明书(SDS)
请选择语言。
如需更多帮助，请联系我 们。
技术规格
CoA及其他文档
请输入批号
批号输入有误。请输入中横线前的4-5个字母数字字符。
示例 CoA
可下载CoA示例。注：该示例不一定是最新批次的CoA。
目前没有该产品的 CoA 示例。
分析图谱
请输入批号
批号输入有误。请输入中横线前的4-5个字母数字字符。
很抱歉，您搜索的分析图谱无法提供。