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CAS RN: 118458-54-1 | 产品编码: A3497
Arcyriaflavin A
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| 规格 | 单价 | 同一天 | 2-3个工作日 | 左侧以上货期 | 数量 |
货期信息
|
|---|---|---|---|---|---|---|
| 20MG |
S$291.00
|
10 | 16 | 下单后约2周内可以发货 |
|
| 产品编码 | A3497 |
纯度/分析方法 
|
>90.0%(HPLC)(qNMR) |
| 分子式/分子量 | C__2__0H__1__1N__3O__2 = 325.33 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷冻 (-20°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| CAS RN | 118458-54-1 |
| Reaxys-RN | 4557421 |
| MDL编号 | MFCD03452662 |
技术规格
| Appearance | Light yellow to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 90.0 area% |
| Purity(qNMR) | min. 90.0 % |
| NMR | confirm to structure |
物性（参考值）
GHS
相关法规
运输信息
| HS编码* | 2933.99-000 |
应用
Arcyriaflavin A: A Potent Inhibitor of Protein Kinases
Arcyriaflavin A is an important member of the indolocarbazole alkaloid family, and was first isolated in 1980 from the slime mold Arcyria denudata.1) This family has potential therapeutic application in the treatment of cancer because of its ability to inhibit protein kinases.2,3) Thera are reports that arcyriaflavin A inhibits cyclin-dependent kinase 4 (CDK49 and calcium/calmodulin-dependent protein kinase II (CaMKII).3,4) It also inhibits proliferation and induces apoptosis of endometriotic cyst stromal cells (ECSCs).5) In addition, arcyriaflavin A has been used a key synthetic intermediate of indolocarbazole alkaloids such as staurosporinone [T4000] which is a protein kinase C (PKC) and leucine-rich repeat kinase 2 (LRRK2) inhibitor.6) (The product is for research purpose only.)
References
- 1) Indole Pigments from the Fruiting Bodies of the Slime Mold Arcyria denudata
- 2) Indolocarbazole natural products: occurrence, biosynthesis, and biological activity
- 3) Arcyriaflavin A monohydrate
- 4) Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitorss
- 5) Arcyriaflavin a, a cyclin D1–cyclin-dependent kinase4 inhibitor, induces apoptosis and inhibits proliferation of human endometriotic stromal cells: a potential therapeutic agent in endometriosis
- 6) An account of synthetic strategies towards indolocarbazole alkaloids: Arcyriaflavin A and staurosporinone (a review)
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