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CAS RN: 546141-08-6 | 产品编码: A3607
URB-597
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- FAAH抑制剂II
- 环己基氨基甲酸3'-氨基甲酰基-[1,1'-联苯]-3-基酯
- N-环己基氨基甲酸3'-(氨基羰基)[1,1'-联苯]-3-基酯
- FAAH Inhibitor II
- 3'-Carbamoyl-[1,1'-biphenyl]-3-yl Cyclohexylcarbamate
- 3'-(Aminocarbonyl)[1,1'-biphenyl]-3-yl N-Cyclohexylcarbamate
产品文档：
| 产品编码 | A3607 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__0H__2__2N__2O__3 = 338.41 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器
|
100MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 546141-08-6 |
| Reaxys-RN | 9795889 |
| MDL编号 | MFCD05863934 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| NMR | confirm to structure |
物性（参考值）
GHS
相关法规
运输信息
| HS编码* | 2924.29-000 |
应用
URB-597: A Potent and Selective Inhibitor of the Enzyme Fatty Acid Amide Hydrolase (FAAH),
Endogenous cannabinoids, such as anandamide (AEA) [A3448] and 2-arachidonoyl glycerol (2-AG) [A3490], are biologically active lipids that activate the CB1 and CB2 cannabinoid receptors. Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system (ECS), which is involved in a variety of physiological processes. Endocannabinoid signaling is terminated by enzymatic hydrolysis, a process mediated by fatty acid amide hydrolase (FAAH) for anandamide and monoacylglycerol lipase (MAGL) for 2-AG. URB-597 (KDS-4103) is a potent and selective inhibitor of the enzyme FAAH, which catalyzes the intracellular hydrolysis of bioactive fatty acid ethanol amides such as anandamide. There are reports that URB-597 increases anandamide levels in the brain of rats and wild-type mice. (The product is for research purpose only.)
References
- Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis
- Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): Effects on anandamide and oleoylethanolamide deactivation
- Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597) (a review)
- The endocannabinoid system as a target for novel anxiolytic and antidepressant drugs (a review)
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