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CAS RN: 23930-19-0 | 产品编码: A3644
Alphaxalone
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| 产品编码 | A3644 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__2__1H__3__2O__3 = 332.48 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| CAS RN | 23930-19-0 |
| Reaxys-RN | 3217240 |
| MDL编号 | MFCD00083468 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 168.0 to 172.0 °C |
| Specific rotation | +105 to +115 deg(C=1, CHCl3) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 170 °C |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | TU4157800 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2914.40-000 |
应用
Alfaxane: A Neurosteroid Action on GABAA Receptors
Alfaxane is a neurosteroid and general anesthetic with minimal cardiorespiratory effects and is used in veterinary practice. There are reports that alfaxalone acts as a positive allosteric modulator on GABAA receptors and, at high concentrations, as a direct agonist of the GABAA receptor. (The product is for research purpose only.)
References
- A review of the pharmacology and clinical application of alfaxalone in cats
- Clinical review of the pharmacological and anaesthetic effects of alfaxalone in dogs
- Structural basis of neurosteroid anesthetic action on GABAA receptors
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