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CAS RN: 484-20-8 | 产品编码: B2840
Bergapten
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| 产品编码 | B2840 |
纯度/分析方法 
|
>98.0%(GC) |
| 分子式/分子量 | C__1__2H__8O__4 = 216.19 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 应避免的情况 | 光 |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 484-20-8 |
| Reaxys-RN | 19560 |
| PubChem物质ID | 87558737 |
| Merck Index (14) | 1157 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 189.0 to 193.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 191 °C |
| 最大吸收波长 | 480 nm (MeOH) |
| 溶解性（可溶于） | 乙醚 |
| 溶解性（微溶于） | 苯, 醇, 氯仿 |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H317 : May cause an allergic skin reaction. H350 : May cause cancer. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P272 : Contaminated work clothing should not be allowed out of the workplace. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | LV1300000 |
运输信息
| HS编码* | 2932.99-000 |
应用
5-Methoxypsoralen (5-MOP): A Photosensitizer in Combination with UV-A irradiation, called PUVA
5-Methoxypsoralen (5-MOP), 8-methoxypsoralen (8-MOP) [X0009] and 4,5',8-trimethylpsoralen [T2267] are naturally occurring linear psoralens (furocoumarins). They have been successfully used as photosensitizers in combination with UV-A irradiation which is called the psoralen-based PUVA (psoralen + UV-A) to manage dermatological diseases, such as psoriasis, vitiligo and cancer. Reportedly, the most important mechanism implies the [2 + 2] cycloaddition photoreaction of psoralen and a DNA pyrimidine nucleobase. The formation of psoralen-pyrimidine adducts prevents the division of the injured cells. In another photoreaction, the activated psoralen can transfer energy to molecular oxygen to generate reactive radicals or excited singlet oxygen which becomes prone to damage the membrane of the harmed cell. In addition, 5-MOP and 8-MOP work as Cytochrome P450 inhibitors. (The product is for research purpose only.)
References
- The evolution of photochemotherapy with psoralens and UVA (PUVA): 2000 BC to 1992 AD (a review)
- 5-Methoxypsoralen: a review of its effects in psoriasis and vitiligo (a review)
- Photoreactivity of Furocoumarins and DNA in PUVA Therapy: Formation of Psoralen－Thymine Adducts
- Mechanism-Based Inactivation of Cytochrome P450 2B1 by 8-Methoxypsoralen and Several Other Furanocoumarins
参考文献
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