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CAS RN: 9041-93-4 | 产品编码: B3972
Bleomycin Sulfate (mixture)
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This product has not been tested for potency and is guaranteed for chemical purity.
| 产品编码 | B3972 |
纯度/分析方法 
|
>85.0%(HPLC) |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 湿气 (吸湿),加热 |
| 包装和容器
|
10MG-Glass Bottle with Plastic Insert （查看图片）, 50MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 9041-93-4 |
| 相关CAS RN
|
11056-06-7 |
| PubChem物质ID | 253659941 |
| Merck Index (14) | 1318 |
| MDL编号 | MFCD00070310 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min.85.0 area% (Sum of A2,B2) |
| BleomycinA2 | 55.0 to 70.0 area% |
| BleomycinB2 | 25.0 to 32.0 area% |
物性（参考值）
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H351 : Suspected of causing cancer. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | EC5991990 |
运输信息
| HS编码* | 2941.90-000 |
应用
Quorum sensing inhibitor
Reference
- The Role of Drug Repurposing in the Development of Novel Antimicrobial Drugs: Non-Antibiotic Pharmacological Agents as Quorum Sensing-Inhibitors
应用
Adeno-associated virus vector transduction enhancer
Bleomycin increases transduction by adeno-associated virus (AAV) vectors.1)
References
- 1) Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens
应用
Reagent for pneumonitis model
References
- Effect of lecithinized-superoxide dismutase on the interstitial pneumonia model induced by bleomycin in mice
- Regulation of type II alveolar epithelial cell proliferation by TGF-beta during bleomycin-induced lung injury in rats
- Production of superoxide and nitric oxide by alveolar macrophages in the bleomycin-induced interstitial pneumonia mice model
- Dual effect of AMD3100, a CXCR4 antagonist, on bleomycin-induced lung inflammation
- Pharmacologic differentiation of inflammation and fibrosis in the rat bleomycin model
- In vivo antioxidant treatment protects against bleomycin-induced lung damage in rats
- Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice
应用
Reagent for pulmonary fibrosis model
References
- Modeling pulmonary fibrosis with bleomycin
- Pulmonary fibrosis: searching for model answers
应用
Bleomycin: A Glycopeptide Antitumor Antibiotics Agent
Bleomycin, a glycopeptide antitumor antibiotic agent, was first discovered in 1966 when the Japanese bacteriologist Umezawa found anticancer activity while screening culture filtrates of Streptomyces verticillus. Activated bleomycin (Fe-bleomycin-O2 complex), the active species, forms in the reaction of bleomycin with Fe(II) and O2. It also forms in the reaction of bleomycin with Fe(III) and peroxide, or bleomycin with superoxide and either Fe(III) or Fe(II). The activated bleomycin produces DNA strand break at 3'-4' bond in a deoxyribose sugar moiety. The mechanism of this bond cleavage reaction and the nature of the active oxidizing species are still open issues.
References
- Mechanisms of bleomycin-induced DNA degradation (a review)
- Cleavage of Nucleic Acids by Bleomycin (a review)
- Bleomycin: New Perspectives on the Mechanism of Action (a review)
- Antitumor Antibiotics: Bleomycin, Enediynes, and Mitomycin (a review)
- Direct Hydrogen-Atom Abstraction by Activated Bleomycin: An Experimental and Computational Study
参考文献
技术文章
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