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CAS RN: 69308-37-8 | 产品编码: B5102
(R)-Baclofen
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技术规格
| Appearance | White to Almost white powder to crystaline |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Specific rotation [a]20/D | 7.0 to 8.0 deg(C=1.6mol/L HCL) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 176 °C(dec.) |
| 比旋光度 [α]D | 7° (C=1,6mol/L HCl) |
| 溶解性（不溶于） | 乙醇, 甲醇 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P272 : Contaminated work clothing should not be allowed out of the workplace. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P284 : Wear respiratory protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | DA8339450 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2922.49-000 |
应用
(R)-Baclofen: The Active Enantiomer of a GABAB Receptor Agonist, Baclofen
(R)-Baclofen (l-baclofen or STX209) is the more active enantiomer of racemic baclofen [B3343] which is a γ-amino butyric acid type B (GABAB) receptor agonist. Baclofen is a muscle relaxant and antispastic, but the precise mechanism of action of baclofen is not fully understood. However, baclofen is a structural analog of the inhibitory neurotransmitter GABA, and may exert its effects by stimulating of the GABAB receptor subtype. (The product is for research purpose only.)
References
- The biological activity of d- and l-baclofen (Lioresal®)
- 3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain
- Metabolic and pharmacokinetic differentiation of STX209 and racemic baclofen in humans
- ACS Chemical Neuroscience Molecule Spotlight on STX209 (Arbaclofen) (a review)
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