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CAS RN: 72679-02-8 | 产品编码: B5315
(S)-3-(Benzoylthio)-2-methylpropionic Acid
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| 产品编码 | B5315 |
纯度/分析方法 
|
>98.0%(GC)(T) |
| 分子式/分子量 | C__1__1H__1__2O__3S = 224.27 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 72679-02-8 |
| Reaxys-RN | 5743935 |
| PubChem物质ID | 354334426 |
| MDL编号 | MFCD00038376 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 67.0 to 71.0 °C |
| Specific rotation [a]20/D | -41.0 to -45.0 deg(C=1,MeOH) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 69 °C |
| 比旋光度 [α]D | -43° (C=1,MeOH) |
| 溶解性（可溶于） | 甲醇 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
| HS编码* | 2930.90-900 |
应用
A Chiral Synthetic Intermediate of Angiotensin Converting Enzyme (ACE) Inhibitors
This product has been used as a chiral synthetic intermediate of angiotensin converting enzyme (ACE) inhibitors, such as captopril and zofenopril.
References
- (Mercaptopropanoyl)indoline-2-carboxylic acids and related compounds as potent angiotensin converting enzyme inhibitors and antihypertensive agents
- Studies on angiotensin-converting enzyme inhibitors. I. Syntheses and angiotensin-converting enzyme inhibitory activity of 2-(3-mercaptopropionyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives
- The use of microbial enzymes for the synthesis of optically active pharmaceuticals
- C. J. Sih, Q. Gu, G. Fulling, S. Wu, D. R. Reddy, Dev. Ind. Microb. 1988, 29, 221.
应用
A Key Synthetic Intermediate of Zofenopril, an ACE Inhibotor
This product is a key synthetic intermediate of zofenopril [Z0041, Ca salt] which is an angiotensin-converting enzyme (ACE) inhibitor with cardioprotective properties.
References
- Biocatalytic synthesis of some chiral pharmaceutical intermediates by lipases
- An improved large scale procedure for the preparation of N-Cbz amino acids
参考文献