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CAS RN: 149198-47-0 | 产品编码: B5715
tert-Butyl (3R,4S)-2-Oxo-4-phenyl-3-[(triethylsilyl)oxy]azetidine-1-carboxylate
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技术规格
| Appearance | Colorless to Light yellow clear liquid |
| Purity(HPLC) | min. 97.0 area% |
| Purity(with Total Nitrogen) | min. 95.0 % |
| NMR | confirm to structure |
物性（参考值）
| 闪点 | 234 °C |
GHS
相关法规
运输信息
| HS编码* | 2933.79-000 |
应用
A β-lactam Synthon for the Synthesis of Microtubule-Stabilizing Antitumor Agents
This reagent has been used as a β-lactam synthon for the synthesis of microtubule-stabilizing antitumor agents, such as paclitaxel [P1632], docetaxel [D4102] and 10-deacetylbaccatin III [D4148].
References
- A highly efficient route to taxotere by the β-lactam synthon method
- A chemoselective approach to functionalize the C-10 position of 1-deacetylbaccatin III. Synthesis and biological properties of novel C-10® Taxol analogs
- Total synthesis of a library of designed hybrids of the microtubule-stabilizing anticancer agents taxol, discodermolide and dictyostatin
- Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents
参考文献
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技术规格
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