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CAS RN: | 产品编码: B6160
BGP-15 Hydrochloride
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纯度/分析方法: >98.0%(HPLC)
别名：
- BGP-15盐酸盐
- N-[2-羟基-3-(哌啶-1-基)丙氧基]吡啶甲脒盐酸盐
- N-[2-羟基-3-(1-哌啶基)丙氧基]-3-吡啶甲脒盐酸盐
- NP-51盐酸盐
- N-[2-Hydroxy-3-(piperidin-1-yl)propoxy]nicotinimidamide Hydrochloride
- N-[2-Hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide Hydrochloride
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产品文档：
| 产品编码 | B6160 |
纯度/分析方法 
|
>98.0%(HPLC) |
| 分子式/分子量 | C__1__4H__2__2N__4O__2·xHCl |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 湿气 (吸湿) |
| 相关CAS RN
|
459809-32-6&66611-37-8 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 200.0 to 204.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 202 °C |
GHS
相关法规
运输信息
| HS编码* | 2933.39-000 |
应用
BGP-15: A PARP Inhibitor and an Insulin Sensitizer
Poly (ADP-ribose) polymerases (PARPs) is a family of enzymes involved in a number of cellular processes such as DNA repair, genomic stability, and apoptosis.1) BGP-15 has been used in cancer research because of its PARP inhibition.2) In addition, BGP-15 has recently reported as a pharmacological inducer of heat shock protein 72 (HSP72) and a new insulin sensitizer agent candidate.3,4) (The product is for research purpose only.)
References
- 1) Role of PARP Inhibitors in Cancer Biology and Therapy
- 2) Effect of Poly(ADP-Ribose) Polymerase Inhibitors on the Ischemia-Reperfusion-Induced Oxidative Cell Damage and Mitochondrial Metabolism in Langendorff Heart Perfusion System
- 3) HSP72 protects against obesity-induced insulin resistance
- 4) Pharmacological overview of the BGP-15 chemical agent as a new drug candidate for the treatment of symptoms of metabolic syndrome
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