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CAS RN: 471-95-4 | 产品编码: B6325
Bufotalin
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纯度/分析方法: >98.0%(HPLC)
别名：
- 蟾毒它灵
- 16β-乙酰氧基-3β,14-二羟基-5β-蟾蜍-20,22-二烯羧酸内酯
- (3β,5β,16β)-16-(乙酰氧基)-3,14-二羟基-蟾蜍-20,22-二烯羧酸内酯
- 16β-Acetoxy-3β,14-dihydroxy-5β-bufa-20,22-dienolide
- (3β,5β,16β)-16-(Acetyloxy)-3,14-dihydroxy-bufa-20,22-dienolide
产品文档：
| 产品编码 | B6325 |
纯度/分析方法 
|
>98.0%(HPLC) |
| 分子式/分子量 | C__2__6H__3__6O__6 = 444.57 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| CAS RN | 471-95-4 |
| Reaxys-RN | 63218 |
| Merck Index (14) | 1477 |
| MDL编号 | MFCD00210248 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation | +3.0 to +5.0 deg(C=0.5, CHCl3) |
| NMR | confirm to structure |
物性（参考值）
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H300 + H310 : Fatal if swallowed or in contact with skin. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P262 : Do not get in eyes, on skin, or on clothing. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing. P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P310 : IF ON SKIN: Wash with plenty of water. Immediately call a POISON CENTER/doctor. P405 : Store locked up. |
相关法规
| RTECS# | EI3150000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | I |
| HS编码* | 2932.20-000 |
应用
Bufotalin: A Cardiotonic Phytosteroid with Anti-Tumor Activities
Bufotalin is a cardiotonic phytosteroid and an active compound of the traditional Chinese medicine ChanSu which exhibits significant anti-tumor activities in many solid tumors and leukemia cell lines. There are reports that bufotalin introduces apoptosis, and prevents migration and invasion of tumor cells. Hence, bufotalin has attracted attention in recent years as an anti-tumor agent. (The product is for research purpose only.)
References
- 1) Bufotalin from Venenum Bufonis inhibits growth of multidrug resistant HepG2 cells through G2/M cell cycle arrest and apoptosis
- 2) Anti-tumor activity and apoptosis-regulation mechanisms of bufalin in various cancers: new hope for cancer patients
- 3) Involvement of Caspases and Apoptosis-Inducing Factor in Bufotalin-Induced Apoptosis of Hep 3B Cells
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技术规格
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