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CAS RN: 357336-20-0 | 产品编码: B6660
Brivaracetam
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| 产品编码 | B6660 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__1H__2__0N__2O__2 = 212.29 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| CAS RN | 357336-20-0 |
| Reaxys-RN | 9629290 |
| MDL编号 | MFCD13152385 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Melting point | 75.0 to 79.0 °C |
| Specific rotation | -56.0 to -62.0 deg(C=1, methanol) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 77 °C |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H336 : May cause drowsiness or dizziness. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust. P271 : Use only outdoors or in a well-ventilated area. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
相关法规
运输信息
| HS编码* | 2933.79-000 |
应用
Brivaracetam: A Selective and High Affinity SV2A Ligand
Brivaracetam (UCB 34714) is chemically related to levetiracetam [L0234]. Synaptic vesicle glycoprotein 2A (SV2A) is a synaptic vesicle protein that regulates potential-dependent neurotransmitter release. Brivaracetam has a selective binding affinity for SV2A that is 15 to 30 times higher than that of levetiracetam, which may contribute to its anticonvulsant activity. (The product is for research use only.)
References
- Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A
- Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: Relationship to anti-convulsant properties
- Narrative Review of Brivaracetam: Preclinical Profile and Clinical Benefits in the Treatment of Patients with Epilepsy
- Synthetic Approaches toward the Synthesis of Brivaracetam: An Antiepileptic Drug (a review)
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