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CAS RN: 67-97-0 | 产品编码: C0314
Cholecalciferol

产品编码 | C0314 |
纯度/分析方法 | >98.0%(HPLC) |
分子式/分子量 | C__2__7H__4__4O = 384.65 |
外观与形状(20°C) | 固体 |
储存温度 | 冷冻 (<0°C) |
储存在惰性气体下 | 存放于惰性气体之中 |
应避免的情况 | 空气,加热 |
包装和容器 | 1G-Glass Bottle with Plastic Insert (查看图片) |
CAS RN | 67-97-0 |
PubChem物质ID | 125308742 |
SDBS (AIST Spectral DB) | 10003 |
Merck Index (14) | 10019 |
MDL编号 | MFCD00078131 |
技术规格
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Specific rotation [a]20/D | +103 to +112 deg(C=0.5, EtOH) |
Absorbance | 0.450 to 0.510(10mg/L, EtOH, 263.0 to 267.0 nm) |
NMR | confirm to structure |
物性(参考值)
熔点 | 86 °C |
比旋光度 [α]D | 108° (C=0.5,EtOH) |
水溶性 | 不溶 |
溶解性(可溶于) | 醇, 氯仿 |
GHS
象形图 |
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信号词 | Danger |
危险性说明 | H300 + H310 + H330 : Fatal if swallowed, in contact with skin or if inhaled. H360 : May damage fertility or the unborn child. H372 : Causes damage to organs through prolonged or repeated exposure. H413 : May cause long lasting harmful effects to aquatic life. |
防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P262 : Do not get in eyes, on skin, or on clothing. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P284 : Wear respiratory protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P310 : IF ON SKIN: Wash with plenty of water. Immediately call a POISON CENTER/doctor. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
相关法规
RTECS# | VS2900000 |
运输信息
UN编号 | UN2811 |
类别 | 6.1 |
包装类别 | II |
HS编码* | 2936.29-000 |
应用
Efflux pump inhibitor
References
- Action of cholecalciferol and alpha-tocopherol on Staphylococcus aureus efflux pumps
应用
Cholecalciferol (Vitamin D3): A Compound for the Maintenance of Normal Skeleton Architecture and Mineral Homeostasis
Cholecalciferol (Vitamin D3) is known for the maintenance of normal skeleton architecture and mineral homeostasis. Vitamin D3 is synthesized from 7-dehydrocholesterol [CAS: 434-16-2] in the skin under the influence of UV light, or it is obtained from food, especially fatty fish. The transformation (hydroxylation) of vitamin D3 is catalyzed by enzymes in the liver and the kidney to produce calcitriol [C3078] (other name: 1α,25-dihydroxyvitamin D3), the active form of vitamin D3. Calcitriol is active in the regulation of the absorption of calcium from the gastrointestinal tract. (The product is for research purpose only.)
References
- Overview of general physiologic features and functions of vitamin D (a review)
- Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease (a review)
- Enzymes involved in the activation and inactivation of vitamin D (a review)
- Vitamin D physiology (a review)
- Analytical measurement and clinical relevance of vitamin D3 C3-epimer (a review)
- The role of vitamin D in reducing cancer risk and progression (a review)
参考文献
文章/手册
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