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CAS RN: 50-22-6 | 产品编码: C0388
Corticosterone
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| 产品编码 | C0388 |
纯度/分析方法 
|
>98.0%(HPLC) |
| 分子式/分子量 | C__2__1H__3__0O__4 = 346.47 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
100MG-Glass Bottle with Plastic Insert （查看图片）, 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 50-22-6 |
| Reaxys-RN | 2339601 |
| PubChem物质ID | 87565517 |
| SDBS (AIST Spectral DB) | 11021 |
| Merck Index (14) | 2538 |
| MDL编号 | MFCD00037715 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 181.0 to 184.0 °C |
| Specific rotation [a]20/D | +220 to +240 deg(C=1, EtOH) |
| Solubility in hot Methanol | very faint turbidity |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 182 °C |
| 比旋光度 [α]D | 223° (C=1,EtOH) |
| 最大吸收波长 | 240 nm (MeOH) |
GHS
相关法规
| RTECS# | GM7650000 |
运输信息
| HS编码* | 2937.29-000 |
应用
Bacterial spore germinant research
Bacterial spores are more resistant to antibiotics and nutritional deficiencies than their vegetative cells and sometimes cause serious problems from the viewpoint of hygiene in clinical treatment and food processing.1) Spore persistence also plays a major role in the recurrence of infections after antibiotic treatment. Molecules that stimulate germination are termed “germinants”1) and the efficacy of germinant administration combined with antibiotics have been evaluated (for example, reports by N. Budi et al.2,3)). Corticosterone has been reported to act as a germinant for Clostridium sordellii spores (EC50 = 12.3 μM) and as an inhibitor for Clostridium difficle spores (IC50 = 451.4 μM).4)
(The product is for research purpose only.)
(The product is for research purpose only.)
References
- 1) Germinants and Their Receptors in Clostridia
- 2) Omadacycline Compared to Vancomycin When Combined with Germinants To Disrupt the Life Cycle of Clostridioides difficile.
- 3) Efficacy of Omadacycline or Vancomycin Combined With Germinants for Preventing Clostridioides difficile Relapse in a Murine Model
- 4) Progesterone Analogs Influence Germination of Clostridium sordellii and Clostriduim difficile Spores In Vitro
参考文献