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CAS RN: 7081-44-9 | 产品编码: C2244
Cloxacillin Sodium Salt Monohydrate
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| 产品编码 | C2244 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__1__9H__1__7ClN__3NaO__5S·H__2O = 475.88 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 湿气 (吸湿),加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 7081-44-9 |
| 相关CAS RN | 61-72-3&642-78-4 |
| Reaxys-RN | 5403885 |
| PubChem物质ID | 87560263 |
| SDBS (AIST Spectral DB) | 52169 |
| MDL编号 | MFCD00150735 |
技术规格
| Appearance | White to Orange to Green powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| Specific rotation [a]20/D | +160 to +169 deg(C=1, H2O)(calcd.on anh.substance) |
| Water | 3.0 to 5.3 % |
物性（参考值）
| 比旋光度 [α]D | 164° (C=1,H2O) |
GHS
相关法规
| RTECS# | XH8750000 |
运输信息
| HS编码* | 2941.10-000 |
应用
Cloxacillin Sodium: A β-Lactamase-Resistant Penicillin
Cloxacillin sodium, an isoxazolyl penicillin, is chemically synthesized from 6-APA [A0800]. Cloxacillin has activity against Gram-positive bacteria, but less activity against Gram-negative bacteria, the same as penicillin G [P1770] [P1772]. It acts as a competitive inhibitor of the enzyme transpeptidase, which is needed by bacteria to make their cell walls. Meanwhile, cloxacillin, oxacillin [O0353] and methicillin are resistant to the enzymes (β-lactamases) which produced by bacteria that destroy β-lactam antibiotics like penicillins and cephalosporins, due to theirs large side-chain, which does not allow the β-lactamases to bind. However, with the widespread use of cloxacillin, antibiotic-resistant strains called cloxacillin-resistant Staphylococcus aureus have become increasingly prevalent worldwide.
References
- Sodium cloxacillin (a review)
- A survey of the kinetic parameters of class C β-lactamases. Penicillins
- Contributions of the AmpC β-lactamase and the acrAB multidrug efflux system in intrinsic resistance of Escherichia coli K-12 to β-lactams
- Solubility of Cloxacillin Sodium in Different Binary Solvents
- Methicillin (cloxacillin)-resistant Staphylococcus aureus strains isolated from bovine mastitis cases
参考文献
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