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CAS RN: 72956-09-3 | 产品编码: C2260
Carvedilol
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 115.0 to 119.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 117 °C |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 甲醇 |
| 溶解性（微溶于） | 乙醇, 乙醚 |
GHS
| 象形图 |
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| 危险性说明 | H411 : Toxic to aquatic life with long lasting effects. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P391 : Collect spillage. |
相关法规
| RTECS# | UA8670000 |
运输信息
| UN编号 | UN3077 |
| 类别 | 9 |
| 包装类别 | III |
| HS编码* | 2933.99-000 |
应用
Carvedilol: A Nonselective β-Adrenoceptor Antagonist with α1-Receptor Antagonistic Activity
Carvedilol is a nonselective β1 and β2-adrenoceptor antagonist1) with α1-receptor antagonistic activity.2) The ratio of β1:β2 adrenergic activity is 7:1,1) and the ratio of α:β adrenergic activity is 1:8.3) Carvedilol is a racemic mixture, and the β-adrenoreceptor blocking activity is present in the S-(-)-enantiomer and α1-adrenergic blocking activity is present in both R-(+) and S-(-)-enantiomers at equal potency.4) Carvedilol also has antioxidant and antiproliferative effects.5) Furthermore, carvedilol is able to stimulate β-arrestin-mediated signaling.6) (The product is for research purpose only.)
References
- 1)Pharmacological Profile of Carvedilol as a β-Blocking Agent with Vasodilating and Hypotensive Properties.
- 2)Hemodynamic differences between carvedilol and labetalol in the cutaneous circulation
- 3)Vasodilating mechanism and response to physiological pressor stimuli of acute doses of carvedilol compared with labetalol, propranolol and hydralazine
- 4)Clinical pharmacokinetics and pharmacodynamics of carvedilol (a review)
- 5)Carvedilol, a new vasodilator and beta adrenoceptor antagonist, is an antioxidant and free radical scavenger (a review)
- 6)A unique mechanism of β-blocker action: carvedilol stimulates β-arrestin signaling
参考文献
技术文章
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