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CAS RN: 69-09-0 | 产品编码: C2481
Chlorpromazine Hydrochloride
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 195.0 to 199.0 °C |
物性（参考值）
| 熔点 | 197 °C |
| 水溶性 | 可溶 |
| 溶解性（可溶于） | 乙醇, 甲醇 |
| 溶解性（不溶于） | 乙醚, 苯 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H330 : Fatal if inhaled. H301 : Toxic if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P284 : Wear respiratory protection. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
相关法规
| RTECS# | SO1750000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | I |
| HS编码* | 2934.30-000 |
应用
Biofilm research
References
- Antifungal activity of promethazine and chlorpromazine against planktonic cells and biofilms of Cryptococcus neoformans/Cryptococcus gattii complex species
- Laser-Irradiated Chlorpromazine as a Potent Anti-Biofilm Agent for Coating of Biomedical Devices
应用
Chlorpromazine Hydrochloride: A Dopamine Inhibitor with Antipsychotic Activity
Chlorpromazine hydrochloride is a phenothiazine antipsychotic agent. The precise mechanism of actions is not fully understood. However, chlorpromazine works as a dopamine inhibitor, and the antagonism central dopaminergic function may be related to the therapeutic effect in psychotic conditions. Chlorpromazine can also produce α-adrenergic receptor antagonist action which may produce hypotension. Besides, it is reported that UV irradiation of chlorpromazine produces reactive free radicals which have DNA damaging properties. (The product is for research purpose only.)
References
- Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs
- Expression and pharmacological characterization of the human D3 dopamine receptor
- Unique binding characteristics of antipsychotic agents interacting with human dopamine D2A, D2B, and D3 receptors
- Review of the genotoxic properties of chlorpromazine and related phenothiazines
- Fifty years chlorpromazine: a historical perspective (a review)
- Simple and simultaneous determination for 12 phenothiazines in human serum by reversed-phase high-performance liquid chromatography
- Extraction and determination of trace amounts of chlorpromazine in biological fluids using hollow fiber liquid phase microextraction followed by high-performance liquid chromatography
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