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CAS RN: 3650-09-7 | 产品编码: C2488
Carnosic Acid (Synthetic)
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纯度/分析方法: >97.0%(T)(HPLC)
别名：
- 鼠尾草酸 (合成)
- (4aR,10aS)-5,6-二羟基-7-异丙基-1,1-二甲基-1,2,3,4,4a,9,10,10a-八氢菲-4a-羧酸 (合成)
- (4aR,10aS)-5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-4a-carboxylic Acid (Synthetic)
产品文档：
| 产品编码 | C2488 |
纯度/分析方法 
|
>97.0%(T)(HPLC) |
| 分子式/分子量 | C__2__0H__2__8O__4 = 332.44 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷冻 (<0°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 光,空气,加热 |
| 包装和容器
|
100MG-Glass Bottle with Plastic Insert （查看图片）, 20MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 3650-09-7 |
| Reaxys-RN | 2707918 |
| PubChem物质ID | 125307807 |
| MDL编号 | MFCD02259459 |
技术规格
| Appearance | White to Yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
| Specific rotation [a]20/D | +182 to +195 deg(C=1, MeOH) |
物性（参考值）
| 熔点 | 190 °C |
| 比旋光度 [α]D | 184° (C=1,MeOH) |
GHS
相关法规
运输信息
| HS编码* | 2918.99-000 |
应用
Efflux pump research / Efflux pump inhibitor
Carnosic acid is a compound known as an abietane diterpene. According to the study using Staphylococcus aureus, carnosic acid (10 μg/ml) showed a 2-fold potentiation of tetracycline activity against XU212 (TetK possessing strain) and 8-fold potentiation of erythromycin activity against RN4220 (Msr possessing strain).1)
(The product is for research purpose only.)
(The product is for research purpose only.)
Reference
- 1) Antibacterial and resistance modifying activity of Rosmarinus officinalis
- Rosmarinus officinalis as an Antioxidant
- Antioxidant Activity of a Rosemary Extract and Its Constituents, Carnosic Acid, Carnosol, and Rosmarinic Acid, in Bulk Oil and Oil-in-Water Emulsion
- Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1
- Carnosic acid and carnosol inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and activation of glutathione metabolism
- Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes
- Carnosic acid, a new class of lipid absorption inhibitor from sage
- 1)M. Tada, T. Ohkanda, J. Kurabe, Chem. Pharm. Bull. 2010, 58, 27.
- 2)M. Tada, PCT Int. Appl. WO 2009060547, 2009.
- 3)M. Tada, TCIMAIL 2012, number 150, 2.
应用
Notice
This product is the synthetic carnosic acid. For your reference, recent reviews on carnosic acid after 2015 are shown on anther carnosic acid [C3477] product application on the website. (The product is for research purpose only.)
应用
Antioxidant study
References
应用
Neuron protective effects study
Reference
应用
Inhibition of adipocyte differentiation study
Reference
应用
Inhibition of human 5-Lipoxigenase study
Reference
应用
Inhibition of lipid absorption study
Reference
应用
Synthesis of carnosic acid
Reference
PubMed Literature
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