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CAS RN: 169590-42-5 | 产品编码: C2816
Celecoxib
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- 塞来昔布
- 4-[5-(4-甲苯基)-3-(三氟甲基)-1H-吡唑-1-基]甲磺酰胺
- 5-(4-甲苯基)-1-(4-磺酰基苯基)-3-(三氟甲基)吡唑
- 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
- 5-(4-Methylphenyl)-1-(4-sulfamoylphenyl)-3-(trifluoromethyl)pyrazole
产品文档：
| 产品编码 | C2816 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__7H__1__4F__3N__3O__2S = 381.37 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| 包装和容器
|
1G-Glass Bottle with Plastic Insert （查看图片）, 200MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 169590-42-5 |
| Reaxys-RN | 7662430 |
| PubChem物质ID | 253660758 |
| Merck Index (14) | 1956 |
| MDL编号 | MFCD00941298 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 161.0 to 165.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 163 °C |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 乙醇 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. H373 : May cause damage to organs through prolonged or repeated exposure. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | DB2944937 |
运输信息
| HS编码* | 2935.90-000 |
应用
Efflux pump research
References
- Repurposing celecoxib as a topical antimicrobial agent
应用
Celecoxib: A Selective Cyclo-Oxygenase-2 (COX-2) Inhibitor
Celecoxib (SC-58635), a nonsteroidal anti-inflammatory drug (NSAID), is a cyclo-oxygenase (COX) inhibitor that exhibits relative selectivity for COX-2 over COX-1 in vitro and in vivo. In theory, a drug such as celecoxib that selectively inhibited COX-2 might block inflammation, pain, and fever produced by prostaglandins while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1. In addition, celecoxib is reported that has anticancer properties.
References
- Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)
- Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis
- The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2
- Clinical pharmacokinetics and pharmacodynamics of celecoxib: a selective cyclooxygenase-2 inhibitor (a review)
- Cyclooxygenase 2: a molecular target for cancer prevention and treatment (a review)
PubMed Literature
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