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CAS RN: 160982-16-1 | 产品编码: C2832
(S)-6-Chloro-4-hydroxy-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine 1,1-Dioxide
![Chemical Structure of (S)-6-Chloro-4-hydroxy-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine 1,1-Dioxide](/medias/C2832.jpg?context=bWFzdGVyfHJvb3R8NTMzOTh8aW1hZ2UvanBlZ3xhREkwTDJnME1DODRPVEl3TnpZMU9ESTFNRFUwTDBNeU9ETXlMbXB3Wnd8Y2VjNjQyYWJlZjRkOGU0NzBmNmIxNzg4YTE1YjQ3ZDYwYjBlNDQ2YzdjOTcyOTYyZTczY2M4M2ZmODhjZjIxMg "(S)-6-Chloro-4-hydroxy-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine 1,1-Dioxide")
![Thumbnail of (S)-6-Chloro-4-hydroxy-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine 1,1-Dioxide](/medias/C2832.jpg?context=bWFzdGVyfHJvb3R8MTYwMjR8aW1hZ2UvanBlZ3xhREEzTDJnME5pODRPVE0wTWpFME56azFNamswTDBNeU9ETXlMbXB3Wnd8NzQ4MjNlOWEyYWUzY2Q2NDhkZjFmMjdiZGM0NTEzZTU3M2Y2Y2E2MGM4NDNhZDQyOTVlYjNjZjI0ZWU4OTExNg)
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![(S)-6-Chloro-4-hydroxy-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine 1,1-Dioxide](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "(S)-6-Chloro-4-hydroxy-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine 1,1-Dioxide")
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 128.0 to 132.0 °C |
| Specific rotation [a]20/D | -4.0 to -6.0 deg(C=1, MeOH) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 130 °C |
| 比旋光度 [α]D | -5° (C=1,MeOH) |
| 溶解性（可溶于） | 甲醇 |
GHS
相关法规
运输信息
| HS编码* | 2934.99-000 |
应用
A Key Synthetic Intermediate of Brinzolamide
This product has been used as a key synthetic intermediate of brinzolamide [B4258] which is a specific carbonic anhydrase (CA) inhibitor specifically carbonic anhydrase II.
References
- Enantioselective Synthesis of Brinzolamide (AL-4862), a New Topical Carbonic Anhydrase Inhibitor. The "DCAT Route" to Thiophenesulfonamides
参考文献