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CAS RN: 23593-75-1 | 产品编码: C2867
Clotrimazole
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技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 143.0 to 147.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 147 °C |
| 最大吸收波长 | 556 nm (Phosphate buffer sol.) |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 甲醇, 乙醇, 二甲基甲酰胺 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H413 : May cause long lasting harmful effects to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | NI4377000 |
运输信息
| HS编码* | 2933.29-000 |
应用
Clotrimazole: A Synthetic Imidazole Antifungal and an IKCA Inhibitor
Clotrimazole is a chemical synthetic imidazole antifungal. It has in vitro strong activity against Candida species, Trichophyton species, Microsporum species and Malassezia furfur. Besides that, clotrimazole has some in vitro activity against certain Gram-positive bacteria. Clotrimazole works to kill individual Candida or fungal cells by altering the permeability of the fungal cell wall. In additon, clotrimazole shows therapeutic effects on sickle cell disease, and etc. by inhibiting membrane intermediate-conductance Ca2+-activated K+ channels (IKCa). (The product is for research purpose only.)
References
- Clotrimazole. Review of its antifungal activity and therapeutic efficacy
- Clotrimazole (a review of its description, properties, synthesis, stability, metabolites, pharmacokinetics, and analysis)
- Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant
- Clotrimazole inhibits cell proliferation in vitro and in vivo
- The antifungal antibiotic, clotrimazole, inhibits chloride secretion by human intestinal T84 cells via blockade of distinct basolateral K+ conductances: demonstration of efficacy in intact rabbit colon and in an in vivo mouse model of cholera
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