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CAS RN: 69712-56-7 | 产品编码: C2936
Cefotetan
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This product has not been tested for potency and is guaranteed for chemical purity.
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
| Specific rotation [a]20/D | +115.0 to +122.0 deg(C=1,0.5%NaHCO3 sol.(0.5%)) |
| NMR | confirm to structure |
物性（参考值）
| 比旋光度 [α]D | 118° (C=1,0.5% NaHCO3) |
| 溶解性（微溶于） | 甲醇 |
GHS
相关法规
| RTECS# | XI0330800 |
运输信息
| HS编码* | 2941.90-000 |
应用
Cefotetan: A (7S)-Methoxy Cephalosporin (Cephamycin)
Cefotetan, a (7S)-methoxy cephalosporin (cephamycin), is chemically synthesized form 7-MAC [M2129]. The steric hindrance effect that is enhanced by introducing (7S)-methoxy into the β-lactam ring significantly increases the stability of β-lactam antibiotics against β-lactamases, and to some extent reduces the problems of bacterial drug-resistance. Cefotetan has a broad spectrum of activity against Gram-negative and Gram-positive bacteria, and is generally more active against Gram-negative bacteria than the ‘first and second generation’ cephalosporins. Cefotetan is particularly active against Enterobacter but has little activity against Pseudomonas aeruginosa.
References
- Cefotetan. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use
- Cefotetan: a review of the microbiologic properties and antimicrobial spectrum
- A simple and sensitive liquid chromatographic technique for the determination of cefotetan disodium in human plasma and its application in a pharmacokinetic study
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