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CAS RN: 41354-29-4 | 产品编码: C3218
Cyproheptadine Hydrochloride Sesquihydrate
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| 产品编码 | C3218 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__1H__2__1N·HCl·1^^1/__2H__2O = 350.88 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
室温 (15°C以下阴凉干燥处) |
| CAS RN | 41354-29-4 |
| 相关CAS RN
|
969-33-5&129-03-3 |
| PubChem物质ID | 354333357 |
| Merck Index (14) | 2773 |
| MDL编号 | MFCD00012538 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 %(after drying) |
| Drying loss | 7.0 to 9.0 % |
物性（参考值）
| 最大吸收波长 | 285 nm (0.05mol/L H__2SO__4) |
| 溶解性（可溶于） | 氯仿 |
| 溶解性（微溶于） | 乙醇 |
| 溶解性（不溶于） | 乙醚 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | TM7050000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2933.39-000 |
应用
Cyproheptadine Hydrochloride: A Potent 5-HT Receptor and Histamine H1 Receptor Antagonist
Cyproheptadine hydrochloride is a 5-HT (serotonin, [S0370 (hydrochloride)]) receptor antagonist with antiserotonin activity comparable with that of LSD. In addition, it is histamine H1 receptor antagonist with potent antihistaminic activity. Meanwhile, it has anticholinergic effect as a side effect. (The product is for research purpose only.)
References
- Antiserotonin-antihistaminic properties of cyproheptadine
- Antimuscarinic effects of antihistamines: quantitative evaluation by receptor-binding assay
- Effects of 5-HT uptake inhibitors, agonists and antagonists on the burying of harmless objects by mice; a putative test for anxiolytic agents
- Comparative anticholinergic activities of 10 histamine H1 receptor antagonists in two functional models
- Cyproheptadine: A review on the description, physical properties, synthesis, metabolism and analysis of cyproheptadine-HCl
- HPLC and chemometric methods for the simultaneous determination of cyproheptadine hydrochloride, multivitamins, and sorbic acid
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