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CAS RN: 530-43-8 | 产品编码: C3258
Chloramphenicol Palmitate
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纯度/分析方法: >97.0%(T)(HPLC)
别名：
- 氯霉素棕榈酸酯
- 棕榈酸氯霉素
- D-(-)-苏式-2-二氯乙酰胺-1-(4-硝基苯基)-1,3-丙二醇棕榈酸酯
- 2,2-二氯-N-[(1R,2R)-1,3-二羟基-1-(4-硝基苯基)-2-丙基]乙酰胺棕榈酸酯
- D-(-)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol Palmitate
- 2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)-2-propyl]acetamide Palmitate
产品文档：
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Argentometric Titration) | min. 97.0 % |
| Melting point | 91.0 to 96.0 °C |
| Specific rotation [a]20/D | +20.5 to +25.4 deg(C=2, EtOH(99.5)) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 94 °C |
| 比旋光度 [α]D | 24° (C=2,EtOH(99.5)) |
| 最大吸收波长 | 271 nm (EtOH) |
| 水溶性 | 微溶 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H351 : Suspected of causing cancer. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | RT4735000 |
运输信息
| HS编码* | 2941.40-000 |
应用
Chloramphenicol Palmitate: A Prodrug of Chloramphenicol
Chloramphenicol palmitate is a poorly water-soluble prodrug of chloramphenicol [C2255] for oral administration as a suspension agnent. The palmitate ester is inactive, requiring hydrolysis to chloramphenicol for anti-bacterial activity. The palmitate ester is hydrolyzed in the small intestine to active chloramphenicol prior to absorption. (The product is for research purpose only.)
References
- Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate
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