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CAS RN: 2259-96-3 | 产品编码: C3392
Cyclothiazide (mixture of isomers)
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| 产品编码 | C3392 |
纯度/分析方法 
|
>95.0%(HPLC) |
| 分子式/分子量 | C__1__4H__1__6ClN__3O__4S__2 = 389.87 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器
|
25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 2259-96-3 |
| Reaxys-RN | 722843 |
| PubChem物质ID | 354335513 |
| Merck Index (14) | 2754 |
| MDL编号 | MFCD00210192 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 %(total of isomer) |
| Elemental analysis(Nitrogen) | 10.20 to 11.20 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 234 °C |
| 最大吸收波长 | 273 nm |
GHS
相关法规
| RTECS# | DK9610000 |
运输信息
| HS编码* | 2935.90-000 |
应用
Cyclothiazide: A Benzothiadiazide Antagonist of AMPA Receptors
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (also known as AMPA receptors) are a class of ionotropic glutamate receptors, and major players in mediating basal synaptic transmission and synaptic plasticity in the mammalian CNS. AMPA-receptor modulation could be a way of adjusting the excitatory–inhibitory balance. Therefore, AMPA receptors are emerging as a new target for epilepsy, depression, etc. Cyclothiazide has been reported as a benzothiadiazide antagonist of AMPA receptors, and a promising tool for analysis of allosteric regulatory mechanisms at AMPA receptors. (The product is for research purpose only.)
References
- Benzothiadiazides inhibit rapid glutamate receptor desensitization and enhance glutamatergic synaptic currents
- Cyclothiazide differentially modulates desensitization of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor splice variants
- Mechanism of glutamate receptor desensitization
- AMPA receptor potentiators: application for depression and parkinson's disease (a review)
- Cyclothiazide (a review of the physical properties, methods of analysis, synthesis and stability of cyclothiazide)
- Preparative isolation of the eutomer of cyclothiazide by high-performance liquid chromatography on a cellulose-derived chiral stationary phase with toluene-acetone as the mobile phase
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