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CAS RN: 1163-36-6 | 产品编码: C3468
Clemizole Hydrochloride
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This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 产品编码 | C3468 |
纯度/分析方法 
|
>98.0%(HPLC) |
| 分子式/分子量 | C__1__9H__2__0ClN__3·HCl = 362.30 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器
|
25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 1163-36-6 |
| 相关CAS RN
|
442-52-4 |
| Reaxys-RN | 3791565 |
| PubChem物质ID | 354335133 |
| Merck Index (14) | 2346 |
| MDL编号 | MFCD00051435 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 11.00 to 12.00 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 241 °C |
| 水溶性 | 可溶 |
| 溶解性（不溶于） | 二乙醚 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | DD6730000 |
运输信息
| HS编码* | 2933.99-000 |
应用
Clemizole Hydrochloride: A Histamine H1 Receptor Antagonist with Anti-Virus and Various Effects
Clemizole hydrochloride is a histamine H1 receptor antagonist1). Recently, it is reported that clemizole inhibits hepatitis C virus (HCV) replication2), and also potently inhibits transient receptor potential channel 5 (TRPC5).3) In addition, clemizole reportedly can be used for the treatment of Dravet syndrome which is often caused by Scn1a mutations, a voltage-gated sodium channel.4) (The product is for research purpose only.)
References
- 1)Comparison of the effects of eleven histamine H1-receptor antagonists on monoamine turnover in the mouse brain
- 2)The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors
- 3)Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5
- 4)Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment
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