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CAS RN: 78574-94-4 | 产品编码: C3469
Cycloastragenol
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| 产品编码 | C3469 |
| 分子式/分子量 | C__3__0H__5__0O__5 = 490.73 |
| 外观与形状（20°C） | 固体 |
储存温度 
|
冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器
|
100MG-Glass Bottle with Plastic Insert （查看图片）, 25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 78574-94-4 |
| Reaxys-RN | 4238706 |
| PubChem物质ID | 354335282 |
| MDL编号 | MFCD24849201 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 241.0 to 245.0 °C |
| Specific rotation [a]20/D | +50.0 to +55.0 deg(C=1, methanol) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 241 °C |
| 比旋光度 [α]D | 49° (C=1.37,MeOH) |
GHS
相关法规
| RTECS# | GX8265000 |
运输信息
| HS编码* | 2932.19-000 |
应用
Cycloastragenol: A Bioactive Triterpenoid Sapogenin Isolated from Astragalus Roots
Cycloastragenol is a bioactive triterpenoid sapogenin isolated from the Chinese herbal medicine Astragalus roots (e.g., Radix Astragali), and the aglycon derivative of astragaloside IV [CAS: 84687-43-4].1,2) It has been reported that cycloastragenol is an interesting bioactive compound. For example, cycloastragenol has been reported as a stimulater of the phosphorylation of extracellular signal-regulated protein kinase (ERK)3), a potent telomerase activator in neuronal cells4,5), and an effective agent to inhibit of endoplasmic reticulum stress.6) (The product is for research purpose only.)
References
- 1)Triterpenoid saponins from Astragalus wiedemannianus Fischer
- 2)Studies on principal components and antioxidant activity of different Radix Astragali samples using high-performance liquid chromatography/electrospray ionization multiple-stage tandem mass spectrometry
- 3)Astragaloside IV and cycloastragenol stimulate the phosphorylation of extracellular signal-regulated protein kinase in multiple cell types
- 4)Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management
- 5)In vitro intestinal absorption and first-pass intestinal and hepatic metabolism of cycloastragenol, a potent small molecule telomerase activator
- 6)Astragaloside IV and cycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium
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